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目的探讨高危型人乳头状瘤病毒(HPV)负荷量与细胞学结果为不典型鳞状上皮增生不除外高度上皮内病变(Atypicalsquamous cells not except high lesion,ASC-H)的病例中宫颈上皮内瘤变(cervical intraepithelial neoplasia,CIN)的病变程度的相关性。方法对2009年1月-2012年11月就诊于我院妇产科门诊,并经宫颈液基细胞学(Thinprep cytology test,TCT)筛查为ASC-H的127例患者,采用杂交捕获二代(HC-2)试验技术进行HPV-DNA病毒负荷量的检测。检测结果根据病毒负荷量多少分为三组:低病毒负荷量组(1.00-10.00)、中病毒负荷量组(10.00-100.00)和高病毒负荷量组(≥100),分析HPV病毒负荷量与CIN的病变程度的相关性。结果 127例ASC-H患者中,HPV阳性患者99例,其中高病毒负荷量组62例,占62.63%,中病毒负荷量组30例,占30.30%,低病毒负荷量组7例,占7.07%。低病毒负荷量中高程度CIN(HSIL)的发生率为57.14%,中病毒负荷量中高程度CIN(LSIL)的发生率为66.67%,高病毒负荷量中高程度CIN的发生率为87.10%,P=0.032,分布差异显著(P<0.05)。结论基本可以判断在ASC-H病例中,CIN病变程度与HPV病毒负荷量呈正相关,即HPV病毒负荷量越高,CIN病变程度越高。
Objective To investigate the relationship between high-risk human papilloma virus (HPV) load and cytological results of atypical squamous cell non-high-grade intraepithelial lesion (ASC-H) (Cervical intraepithelial neoplasia, CIN) the degree of lesion correlation. Methods A total of 127 patients with obstetrics and gynecology clinics from January 2009 to November 2012 who were screened for ASC-H by Thinprep cytology test (TCT) were used to capture the second generation (HC-2) test technique for HPV-DNA viral load testing. The detection results were divided into three groups according to the amount of virus load: low viral load group (1.00-10.00), moderate viral load group (10.00-100.00) and high viral load group (≥100) Correlation of the severity of CIN. Results Among the 127 patients with ASC-H, 99 were HPV-positive patients, 62 of them were high-virus-load group, accounting for 62.63%, 30 were moderate-virus burden group, 30.30% were in high-virus load group, 7 were low- %. The incidence of high-level CIN (HSIL) was 57.14% in low viral load, 66.67% in high-load CIN (LSIL), and 87.10% in high-load of high-dose CIN 0.032, the distribution difference was significant (P <0.05). Conclusion It can be basically judged that in ASC-H cases, the degree of CIN lesion is positively correlated with the load of HPV virus, that is, the higher the load of HPV virus, the higher the degree of CIN lesion.