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目的通过联合检测血清甲胎蛋白(AFP)和P53抗体在原发性肝癌患者中的分布状况(阳性率),分析血清AFP和P53抗体与肝癌病理分化程度的关系。方法采用化学发光法测定患者血清AFP含量,用ELISA法测定患者血清P53抗体的水平,并与肝癌病理分化程度进行相关分析。结果 50例原发性肝癌患者血清AFP阳性率为78.00%(39/50),血清P53抗体阳性率为48.00%(24/50)。血清AFP含量和P53抗体滴度与肝细胞性肝癌的分化程度均呈负相关,即患者血清AFP和P53抗体含量越高,其病理分化程度越低。结论联合检测肝细胞肝癌患者血清中甲胎蛋白及P53抗体的含量和表达水平,可能有助于肝细胞肝癌患者的早期诊断和治疗。
Objective To analyze the relationship between serum AFP and P53 antibodies and pathological differentiation of hepatocellular carcinoma (HCC) by detecting the distribution (positive rate) of serum AFP and P53 antibodies in patients with primary liver cancer. Methods The level of AFP in serum was determined by chemiluminescence method. The level of serum P53 antibody was determined by ELISA. The correlation was analyzed with the degree of pathological differentiation of HCC. Results The positive rate of serum AFP in 50 patients with primary liver cancer was 78.00% (39/50), and the positive rate of serum P53 antibody was 48.00% (24/50). Serum AFP levels and P53 antibody titers were negatively correlated with the degree of hepatocellular carcinoma differentiation, ie, the higher the serum AFP and P53 antibody levels, the lower the degree of pathological differentiation. Conclusion The combined detection of serum levels of alpha-fetoprotein and P53 antibody in hepatocellular carcinoma patients may be helpful for the early diagnosis and treatment of patients with hepatocellular carcinoma.