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目的评价准分子激光原位角膜磨镶术(LASIK)矫正近视术后5年的临床效果。设计回顾性病例系列。研究对象行LASIK手术的近视眼患者64例(126眼)。方法回顾性分析126眼按近视屈光度等效球镜值-3．00D～-6．00D、-6．25D～-10．00D和-10．38D～-19．88D分为A、B、C 3个组行LASIK手术者,术前及术后观察患者的视力、屈光状态、眼前节、眼底及眼压情况,术后随访5年。主要指标视力、眼压、屈光度及并发症。结果术后5年裸眼视力≥1．0者A组为87．2％,B组69．1％,C组3I．3％；裸眼视力≥0．5者A组为100％,B组98．2％,C组75．0％。术后5年屈光度为A组-0．70D±0．52D,B组-1．06D±0．13D,C组-2．46D±2．14D。A、B两组间比较差异无统计学意义(P=0．230)；A、C两组(P=0．008)和B、C两组(P=0．021)间比较差异均有统计学意义。术后5年A、B、C三组屈光度在±1．00D以内者分别占68．3％、45．0％、23．5％。A、B、C三组术后5年眼压分别是(11．91±2．35)mmHg、(11．31±2．20)mmHg和(9．24±2．20)mmHg,A、C两组(P=0．006)和B、C两组(P=0．031)间比较差异均有统计学意义。B组和C组各有1例主诉眩光。B组1例(2眼)术后1个月时出现激素性高跟压,C组1跟术后2年发生孔源性视网膜脱离。结论LASIK术后5年是安全、有效的,中高度近视明显好于超高度近视。(眼科,2006,15：312-314)
Objective To evaluate the clinical effect of laser in situ keratomileusis (LASIK) for correction of myopia after 5 years. Design retrospective case series. Sixty-four patients (126 eyes) with myopia underwent LASIK. Methods Retrospectively analyzed 126 myopic astigmatism equivalent spherical values -3.00D ~ -6.00D, -6.25D ~ -10.00D and -10.38D ~ -19.88D divided into A, B, C Three patients underwent LASIK surgery. Visual acuity, refractive status, anterior segment, fundus and intraocular pressure were observed before and after operation. The patients were followed up for 5 years. The main indicators of vision, intraocular pressure, diopter and complications. Results After 5 years of uncorrected visual acuity ≥ 1.0, 87.2% were in group A, 69.1% in group B, and 3I in group C. 3%; uncorrected visual acuity ≥0.5 100% in group A, group B 98.2%, group C 75.0%. The 5-year postoperative diopter was -0.70D ± 0.52D in A group, -1.06D ± 0.13D in B group, -2.46D ± 2.14D in C group. There was no significant difference between A and B groups (P = 0.230). There was significant difference between A and C groups (P = 0.008) and B and C groups (P = 0.021) Statistical significance. Five years postoperatively, A, B and C groups accounted for 68.3%, 45.0% and 23.5% respectively within ± 1.00D. The intraocular pressure (IOP) in group A, B and C after operation for 5 years were (11.91 ± 2.35) mmHg, (11.31 ± 2.20) mmHg and (9.24 ± 2.20) mmHg, respectively. The differences between the two groups (P = 0.006) and B and C (P = 0.031) were statistically significant. One patient in Group B and C complained of glare. Group B 1 case (2 eyes) 1 month after the emergence of hormone-induced high-pressure, C group 1 and 2 years after the occurrence of rhegmatogenous retinal detachment. Conclusions Five years after LASIK, it is safe and effective, and the myopia in middle and high degree is obviously better than the superhigh myopia. (Ophthalmology, 2006,15: 312-314)