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越来越多的证据表明,树突细胞(DC)在调节获得性免疫中起着重要的作用。DC对来源于微生物感染、变应原、气道组织微环境的信号异常敏感,成熟的DC极化初始的T细胞分化成辅助性T细胞2效应细胞,或者向调节性T细胞分化,诱导免疫耐受的形成。气道在接受到各种炎性刺激信号下,DC迅速从循环系统向气道募集,并在呼吸道黏膜形成一个紧密的网络系统,参与免疫调节反应。动物实验已经证实了DC在引发及维持过敏性气道炎症中的作用,过敏性鼻炎及哮喘患者的气道黏膜DC数目增多,过敏机体与正常机体DC的功能存在差异。该文就DC在过敏性气道炎症中作用的最新研究进展作一综述。
There is growing evidence that dendritic cells (DCs) play an important role in the regulation of adaptive immunity. DCs are sensitive to signals from microbial infections, allergens and airway tissue microenvironment, and mature DC polarized initial T cells differentiate into helper T cell 2 effector cells, or differentiate into regulatory T cells, and induce immunity The formation of tolerance. Airway received a variety of inflammatory stimuli signal, DC rapidly recruited from the circulatory system to the airway and respiratory tract mucosa to form a tight network system involved in immune response. Animal experiments have confirmed the role of DC in triggering and maintaining allergic airway inflammation. Allergic rhinitis and asthma in patients with increased number of airway mucosa DC, allergic and normal body DC function differences. This article reviews the recent progress of DC in the role of allergic airway inflammation.