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A simplified procedure for enantioselective synthesis of (S)-(+)-2-(6-methoxyl-2- naphthyl) propionic acid ((S)-(+)-naproxen), starting from (6-methoxy-a-naphthyl) -1-propanone, with D-mannitol as auxiliary catalyzed by SmCl3 in onepot is described. The yield is 87.5 %(ee value 99 %).
A simplified procedure for enantioselective synthesis of (S) - (+) - 2- (6-methoxyl-2-naphthyl) propionic acid ) -1-propanone, with D-mannitol as auxiliary catalyzed by SmCl3 in one pot is described. The yield is 87.5% (ee value 99%).