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目的观察小剂量胰岛素辅助治疗儿童脓毒症的临床疗效。方法将重症监护病房脓毒症患儿165例,随机分为观察组83例和对照组82例。2组患儿住院后均予以传统方法治疗,在此基础上,观察组给予小剂量胰岛素治疗,对照组给予5%葡萄糖溶液进行静脉滴注,检测并比较2组患儿治疗前后血糖浓度、白细胞(WBC)、降钙素原(PCT)、C反应蛋白(CRP)、丙氨酸氨基转移酶(ALT)、肌酸激酶同工酶MB型(CK-MB)等指标。结果治疗后2组患儿血糖浓度、WBC、PCT、CRP、ALT、CK-MB均显示降低趋势,但观察组较对照组下降更明显,差异均具有统计学意义(P<0.05)。结论小剂量胰岛素对儿童脓毒症有良好的辅助治疗效果,值得进行临床推广。
Objective To observe the clinical efficacy of low-dose insulin in the treatment of sepsis in children. Methods 165 cases of sepsis in intensive care unit were randomly divided into observation group (n = 83) and control group (n = 82). The patients in both groups were treated by traditional method after being hospitalized. On the basis of this, the observation group was treated with low-dose insulin and the control group with 5% dextrose solution for intravenous drip. The levels of blood glucose, leucocytes WBC, PCT, CRP, ALT and CK-MB were measured. Results After treatment, blood glucose levels, WBC, PCT, CRP, ALT and CK-MB in both groups showed a trend of decrease, but the difference between the observation group and the control group was more significant (P <0.05). Conclusion Low-dose insulin has a good adjuvant treatment effect on sepsis in children, which is worthy of clinical promotion.