基质金属蛋白酶 (m atrix m etalloproteinases,MMPs)是一组锌离子依赖的蛋白水解酶 ,在 ECM降解中起着重要作用。目前研究表明 ,MMPs活性异常不仅能促进肿瘤血管形成 ,还是人类多种肿瘤侵袭和转移的必要条件。本文就与肺癌侵袭和转移有关的 MMPs研究作一综述 Matrix Metalloproteinases (MMPs) are a group of zinc ion-dependent proteolytic enzymes that play an important role in the degradation of ECM. The current study shows that abnormal MMPs activity can not only promote tumor angiogenesis, but also a variety of human invasion and metastasis of the necessary conditions. This review summarizes the studies on MMPs involved in the invasion and metastasis of lung cancer