血清中半胱天冬氨酸蛋白酶活性可反映慢性丙型肝炎病毒感染肝脂肪化程度

来源 :世界核心医学期刊文摘(胃肠病学分册) | 被引量 : 0次 | 上传用户:hongyun64
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Hepatic steatosis is a frequent histological alteration in chronic hepatitis C virus (HCV) infection that sensitizes the liver to cell injury, inflammation, and fibrosis via unclear mechanisms. Although apoptosis has been implicated in various liver diseases, its importance in HCV-associated steatosis is largely unknown. In this study, we investigated the role of caspases, the key regulators of apoptosis, and employed two novel caspase assays, an immunological and a luminometric enzyme test, to detect hepatic caspase activation in sera from HCV patients with different grades of steatosis. Our data show that increased caspase activation can be found not only in liver biopsies, but also in sera from HCV patients with liver steatosis. Patients with steatosis exhibited significantly higher serum levels of caspase activity compared with normal healthy individuals. Moreover, the extent of steatosis closely correlated with serum caspase activity, whereas in particular in cases of low or moderate steatosis, no correlation was found with aminotransferase levels. In conclusion, apoptotic caspase activation is considerably elevated in HCV-associated steatosis. More importantly, our data imply that measurement of caspase activation might be a sensitive serum biomarker to detect liver steatosis in patients with chronic HCV infection and other liver diseases. Hepatic steatosis is a frequent histological alteration in chronic hepatitis C virus (HCV) infection that sensitizes the liver via cellarrhea, inflammation, and fibrosis via unclear mechanisms. Although apoptosis has been implicated in various liver diseases, its importance in HCV-associated steatosis is great unknown. In this study, we investigated the role of caspases, the key regulators of apoptosis, and employed two novel caspase assays, an immunological and a luminometric enzyme test, to detect hepatic caspase activation in sera from HCV patients with different grades of steatosis Our data show that increased caspase activation can be found not only in liver biopsies, but also in sera from HCV patients with liver steatosis. steatosis closely correlated with serum caspase activity, in particular in cases of low or moder a more importantly, our data imply that measurement of caspase activation might be a sensitive serum biomarker to detect liver steatosis in patients with chronic HCV infection and other liver diseases.
其他文献
在新课程改革的背景下,小组合作法是一种新型的教学方法,这种教学方法成为提高课堂效率的有效途径。同时小组合作法一改以前传统的教学方式,充分调动了学生学习的主动性。一
Objective To describe the epidemiologic features of an outbreak of severe acute respiratory syndrome (SARS) in urban and suburb areas in Beijing and to explore
经济发展和国家兴衰问题是经济学理论的一个永恒的主题。在现代经济学中,除了新古典经济学的经济增长理论以外,讨论这一重大主题,并形成自己独立理沦体系的有两个著名代表:
关于技术进步对经济增长的影响,古典经济学家,尤其是马克思主义经典作家多有阐述。但是,有关科技进步影响经济增长程度的研究,国外从50年代末期才开始,著名经济学家罗伯特·
酒店客房、航班座位、旅游团名额是在线旅游销售的三个基本产品,自由行、差旅管理、MICE等衍生产品都是针对不同细分目标市场而对三大基本产品的不同组合。在线旅游销售应注
本文在分析质心位置对章动角、空气动力和力矩系数影响的基础上,研究了质心位置对旋转稳定弹丸的动态稳定性、陀螺稳定性和追随稳定性的影响。提出了提高射程和减小散布的弹
现行教材利用简易方程把分数除法应用题转化为分数乘法应用题,解答两种类型的问题可以使用一种思路,这可以降低教学难度,降低学生学习的难度,便于他们理解。分数乘除法应用题
初中语文教学体现学生的主体地位离不开教师高效的指导。教师要以生为本,以学定教,运用多媒体课件辅助初中语文教学。 The teaching of junior high school Chinese teachin
慢性乙型肝炎由于病毒持续感染,免疫功能紊乱,致使病情迁延不愈,治疗非常困难。当前,虽有多种抗乙型肝炎病毒药物用于临床,但疗效不甚理想。公认治疗慢性乙型肝炎最有效的药
为了避免在再入大气层时造成结构损坏,为了成功地突破敌人的防御系统和准确地击中目标,弹头的制导和控制就显得日益重要。近二十年来,美苏两国在弹头技术领域进行了大量的研