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目的比较CTX、ADM联合CF+5-Fu持续滴注方案与CAF方案治疗晚期乳腺癌的近期疗效与毒性反应。方法将64例晚期乳腺癌患者采用信封抽签法随机分组,CTX、ADM联合CF+5-Fu持续滴注方案为观察组,CAF方案为对照组,平均化疗2.5个周期。结果观察组有效率为71.88%(23/32),对照组为43.75%(14/32),两组有效率比较有显著性差异,P<0.05;观察组KPS改善率为75.00%(24/32),对照组46.88%(15/32),两组比较有显著性差异,P<0.05;观察组白细胞下降及血小板减少分别为71.88%(23/32)、62.50%(20/32),对照组分别为43.75%(14/32)、28.13%(9/32),两组比较均有显著性差异,P<0.05;观察组恶心呕吐、口腔粘膜炎、腹泻发生率分别为75.00%(24/32)、50.00%(16/32)、46.88%(15/32),对照组分别为50.00%(16/32)、18.75%(6/32)、21.88%(7/32),两组比较均有显著性差异,P<0.05。结论CTX、ADM联合CF+5-Fu持续滴注治疗晚期乳腺癌有效率高,毒性反应较明显,但病人可以耐受。
Objective To compare the short-term effects and toxicities of CTX and ADM combined with CF + 5-Fu continuous infusion and CAF regimen in the treatment of advanced breast cancer. Methods Sixty - four patients with advanced breast cancer were randomized by enumeration of lottery. CTX and ADM combined with CF + 5-Fu continuous infusion were used as the observation group. The CAF regimen was used as the control group. The average chemotherapy duration was 2.5 cycles. Results The effective rate of the observation group was 71.88% (23/32) and that of the control group was 43.75% (14/32), the effective rate of the two groups was significantly different (P <0.05). The improvement rate of KPS in the observation group was 75.00% 32) in the control group and 46.88% (15/32) in the control group, with significant difference between the two groups (P <0.05). The leukopenia and thrombocytopenia in the observation group were 71.88% (23/32) and 62.50% (20/32) The control group were 43.75% (14/32) and 28.13% (9/32) respectively, with significant difference between the two groups (P <0.05). The incidences of nausea and vomiting, oral mucositis and diarrhea in the observation group were 75.00% 50.00% (16/32) and 46.88% (15/32) respectively in the control group and 50.00% (16/32), 18.75% (6/32) and 21.88% (7/32) There were significant differences between groups, P <0.05. Conclusion CTX, ADM combined with CF + 5-Fu continuous infusion of advanced breast cancer with high efficiency, more obvious toxicity, but patients can tolerate.