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目的:对次氯酸钠窦腔滴注液的制备及其稳定性进行研究,拓宽次氯酸钠的用途,为临床提供新制剂。方法:制备采取先配成2.5％次氯酸钠溶液和7.5％磷酸二氢钠溶液,临用时将上述两液各10 ml加至0.9％氯化钠注射液500 ml中作窦腔滴注.稳定性采用留样观察法。结果:2.5％次氯酸钠液,pH=13时,t0.9为170 d,加入氯化硼作为稳定剂,t0.9为306d,0.05％次氯酸钠窦腔滴注液,pH=7.2,含氮化硼0.015μg·ml-1时有效期为18 d,临床试用疗效满意。结论:次氯酸钠窦腔滴注液可作为治疗鼻窦炎常规制剂应用,其在碱性(pH=13)环境下稳定,加入氮化硼后稳定性显著增高。
Objective: To study the preparation and stability of sodium hypochlorite sinus cavity instillation, broaden the use of sodium hypochlorite and provide a new preparation for clinical application. Methods: Prepare first 2.5% sodium hypochlorite solution and 7.5% sodium dihydrogen phosphate solution, the clinical use of the two liquids of each 10 ml added to 0.9% sodium chloride injection 500 ml sinus infusion. Stability using Sample-like observation method. Results: 2.5% sodium hypochlorite solution, pH = 13, t0.9 for 170 d, add boron chloride as a stabilizer, t0.9 for 306d, 0.05% sodium hypochlorite sinus cavity infusion, pH = 7.2, containing boron nitride 0.015μg · ml-1 valid for 18 days, clinical trials with satisfactory results. CONCLUSION: Sodium hypochlorite sinusoidal instillation can be used as a routine preparation for the treatment of sinusitis. It is stable in alkaline (pH = 13) environment, and its stability is significantly increased after adding boron nitride.