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目的探讨加巴喷丁对带状疱疹后遗神经痛(PHN)患者疼痛的作用及对生活质量(QOL)的影响。方法48例PHN患者随机分为2组,对照组采用传统药物治疗,治疗组采用口服加巴喷丁治疗。采用视觉模拟评分(VAS)评价患者治疗前、治疗后1周、2周和4周疼痛程度。采用生活质量SF-36表中国版对2组患者治疗前及治疗后4周生活质量进行评估比较。结果加巴喷丁组治疗后1、2和4周的VAS评分分别为3·96±1·48、3·31±1·18和2·92±1·25,明显低于对照组VAS评分(P<0·01)。治疗后4周SF-36生活质量评分除躯体功能领域外,显著高于治疗前和对照组评分(P<0·05)。结论加巴喷丁可明显减轻PHN患者疼痛,改善生活质量。
Objective To investigate the effect of gabapentin on pain in patients with postherpetic neuralgia (PHN) and its effect on quality of life (QOL). Methods 48 cases of PHN were randomly divided into two groups. The control group was treated with traditional medicine. The treatment group was treated with oral gabapentin. Visual analogue scale (VAS) was used to assess the patient’s pain levels 1 week, 2 weeks, and 4 weeks after treatment. The quality of life of two groups of patients before treatment and after 4 weeks of treatment was compared with the quality of life SF-36 Chinese version. Results The VAS scores of 1, 2, and 4 weeks after treatment in gabapentin group were respectively 3.96 ± 1.48, 3.31 ± 1.18 and 2.92 ± 1.25, which were significantly lower than those in control group (P < 0 · 01). SF-36 quality of life score at 4 weeks after treatment was significantly higher than that before treatment and control group (P0.05), except for the body function area. Conclusion Gabapentin can significantly reduce the pain in PHN patients and improve the quality of life.