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Clusterin(CLU)是一种凋亡相关蛋白,广泛存在于人体的各种组织和体液中,在多种病理生理过程中都发挥重要作用。研究表明CLU表达上调与多种肿瘤发生有关。在膀胱癌的研究中发现,CLU与其发生发展及预后有着密切的联系,并且以CLU为靶点的治疗也取得一定的效果。本文就近年来CLU在膀胱癌中的研究进展作一综述。
Clusterin (CLU) is an apoptosis-related protein that is widely found in various tissues and fluids of the human body and plays an important role in a variety of pathophysiological processes. Studies have shown that CLU upregulation and a variety of oncogenesis. In the study of bladder cancer, CLU was found to have a close relationship with its development and prognosis, and the treatment with CLU also achieved certain results. This review summarizes the research progress of CLU in bladder cancer in recent years.