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大气颗粒物(PM)是指悬浮在大气中的固体和液体颗粒物的总称。按其粒径的不同可分为PM10、PM2.5、PM0.1等。流行病学资料显示,大气颗粒物与心血管疾病的发病率和死亡率有关。但目前有关这方面的研究并不多。本文总结了部分相关研究,归纳总结PM致心血管疾病的可能机制:自由基与氧化损伤,系统炎症以及转录因子、炎症相关因子的激活,对心肌离子通道的影响,细胞钙稳态破坏,自主神经的影响等。从而为PM致心血管疾病的防治提供一定的理论基础。
Atmospheric particulate matter (PM) refers to the total suspended solids in the atmosphere and liquid particles. According to their different particle size can be divided into PM10, PM2.5, PM0.1 and so on. Epidemiological data show that atmospheric particulate matter and the incidence of cardiovascular disease and mortality related. However, there are not many studies in this area at present. This article summarizes some of the relevant studies and summarizes the possible mechanisms of PM-induced cardiovascular disease: free radical and oxidative damage, systemic inflammation and activation of transcription factors, inflammation-related factors, effects on myocardial ion channels, cellular calcium homeostasis, autonomic Nervous effects and so on. Thus providing a certain theoretical basis for the prevention and treatment of cardiovascular disease caused by PM.