糖尿病大血管病变的发生机制十分复杂 ,目前认为与黏附分子的异常表达有关。1　黏附分子概述　黏附分子是位于细胞膜表面的一类大分子糖蛋白 ,表达于循环白细胞和组织固有细胞表面 ,通过介导细胞与细胞间、细胞与细胞外基质相互黏附 ,从而促使白细胞贴壁、外渗、游走、聚集、抗 The pathogenesis of diabetic macroangiopathy is very complex, and is currently thought to be related to the abnormal expression of adhesion molecules. An Overview of Adhesion Molecule Adhesion molecule is a kind of macromolecule glycoprotein located on the surface of cell membrane. It is expressed on the surface of circulating leucocytes and innate cells of tissues. By adhering cells to cells and cells to extracellular matrix, adhesion molecules promote adhesion of leucocytes, Extravasation, migration, aggregation, resistance