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目的:利用中国双生子登记系统数据,对共同抚养和分开抚养的双生子分别进行双生子两成员慢性病危险因素相似性的比较,以了解分开抚养的双生子研究设计在国内的可行性,并探讨危险因素是否受到抚养环境影响。方法:样本选自中国双生子登记系统的青岛子系统和丽水子系统,其中青岛505对,丽水503对。了解双生子分开抚养情况,并比较吸烟、饮酒、血压、体质指数、腰臀比在共同抚养和分开抚养的双生子两成员中的相似性。结果:不同地区双生子分开抚养比例存在一定差异(青岛0.6%,丽水5.4%)。分开抚养的异卵双生子在丽水仅募集到9对,其多数指标的组内相关系数在统计学上不具有显著性。抚养环境可能影响舒张压和吸烟行为,但是对收缩压、体质指数、腰臀比以及饮酒行为的影响尚不明确。结论:分开抚养的双生子设计为慢性病危险因素的研究提供了一种新的思路,其可以在中国双生子登记系统中实现,但是目前登记系统的样本量不够,需要进一步扩充登记双生子来支持更深入的研究。
OBJECTIVE: To compare the similarities of risk factors of twins in twins with and without twins based on the data of China twins registration system in order to find out the feasibility of twins living separately in China Whether the risk factors are affected by the rearing environment. Methods: The sample was selected from the Qingdao Subsystem and Lishui Subsystem of the Twin System in China, including 505 pairs in Qingdao and 503 pairs in Lishui. Understanding twin dependency status and comparing similarities in smoking, alcohol consumption, blood pressure, body mass index, waist-hip ratio among twins who were co-housed and separated. Results: There were some differences in the dependency ratio of twins in different regions (Qingdao 0.6%, Lishui 5.4%). Divorced twins raised separately in Lishui recruited only 9 pairs, most of the indicators of the group correlation coefficient was not statistically significant. The recuperation environment may affect diastolic blood pressure and smoking behavior, but the effects on systolic blood pressure, body mass index, waist-hip ratio and drinking behavior are not yet clear. CONCLUSIONS: Twins-dependent design provides a new way of thinking about the risk factors for chronic diseases and can be implemented in the twin-child registration system in China. However, the current enrollment system has not enough samples and needs to be further expanded to register twins to support Further research.