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目的分析猪链球菌2型感染部分病例的临床特征及治疗效果。方法回顾分析68例2005年夏季四川省猪链球菌2型感染的临床及病原学确诊的患者资料,从流行病学、临床特征及治疗效果等方面进行总结和分析。结果猪链球菌2型感染流行于6~8月,传染源主要为猪,易感人群主要为农民,常见的暴露方式为宰杀、洗切病/死猪肉。临床表现为急起畏寒、发热、头昏、头痛、全身不适及疼痛,重者出现休克及昏迷。临床类型主要有单纯败血症型、休克型、脑膜炎型及混合型4型。所分离的猪链球菌2型均对四环素耐药,对其它多种抗菌药物均敏感。本组68例患者治疗后总有效率为76.5%(52/68),病死率为23.5%(16/68)。有休克的患者治疗后有效率为42.3%(11/26),病死率为57.7%(15/26)。化脓性脑膜炎患者治疗的有效率为97.5%(39/40)。结论猪链球菌2型感染的主要临床表现为化脓性脑膜炎和休克。治疗效果以脑膜炎型为好,休克型及混合型差,病死率高。
Objective To analyze the clinical features and therapeutic effects of some cases of Streptococcus suis type 2 infection. Methods The clinical and etiological data of 68 cases of Streptococcus suis serotype 2 in Sichuan Province during the summer of 2005 were retrospectively analyzed. The epidemiology, clinical features and therapeutic effects were summarized and analyzed. Results Streptococcus suis type 2 infection prevailed from June to August. The main source of infection was pigs. The predominant population was mainly peasant. The common exposure methods were slaughter, wash-cut disease / dead pork. Clinical manifestations of acute chills, fever, dizziness, headache, general malaise and pain, severe cases of shock and coma. The main clinical types are simple sepsis type, shock type, meningitis type and mixed type 4. The isolated Streptococcus suis type 2 are resistant to tetracycline, a variety of other antimicrobials are sensitive. The group of 68 patients after treatment, the total effective rate was 76.5% (52/68), the mortality rate was 23.5% (16/68). After treatment, the effective rate of the patients with shock was 42.3% (11/26) and the case fatality rate was 57.7% (15/26). The treatment of patients with purulent meningitis was 97.5% (39/40). Conclusion The main clinical manifestations of Streptococcus suis type 2 infection are purulent meningitis and shock. Treatment of meningitis type is good, shock type and mixed type, high mortality.