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目的 :评价中药十复生胶囊对吗啡依赖性猴的脱毒治疗作用。方法 :采用吗啡依赖性猴自然戒断治疗模型 ,评价十复生胶囊对吗啡依赖性猴戒断症状的抑制作用 ,并与可乐定进行比较。结果 :在吗啡依赖性猴自然戒断治疗模型上 ,十复生胶囊 2个剂量组 (0 .5 ,0 .2 g/kg)的戒断症状分值明显低于NS组 (P <0 .0 5 ) ,与可乐定的疗效相当 ;在控制体重下降方面 ,以 0 .5 g/kg组最好 ,与NS组比有显著性差异 (P <0 .0 5 ) ,而且 2个剂量组的作用都优于可乐定 (P <0 .0 5 )。结论 :十复生胶囊对吗啡依赖性猴的戒断症状的脱毒治疗效果肯定 ,其作用与可乐定相当 ,而且在某些方面优于可乐定
Objective: To evaluate the detoxification of morphine-dependent monkeys treated with traditional Chinese medicine Decoction. Methods: Morphine-dependent monkeys were treated with natural withdrawal model to evaluate the inhibitory effect of Shushen Capsule on withdrawal symptoms of morphine-dependent monkeys and compared with clonidine. Results: The morphine withdrawal syndromes in morphine-dependent monkeys were significantly lower than those in the NS group (P <0. 0) in the two dose groups (0.5, 0.2 g / kg) 5), and the same effect of clonidine; in the control of weight loss, the best 0. 5 g / kg group, compared with the NS group had a significant difference (P <0.05), and 2 dose group The effects were better than clonidine (P <0.05). CONCLUSIONS: Shusunsheng Capsule affirmed the efficacy of detoxification of withdrawal symptoms in morphine-dependent monkeys, which is comparable to clonidine and superior to clonidine in some aspects