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目的研究并探讨经阴道超声测量宫颈长度联合基质金属蛋白酶-8(MMP-8)检测对先兆早产的预测价值。方法 80例先兆早产孕妇作为观察组,80例正常孕妇作为对照组,对两组孕妇进行阴道超声宫颈长度测量、MMP-8检测,比较两组孕妇的宫颈长度、MMP-8表达水平,计算宫颈长度测量联合MMP-8检测对早产的诊断敏感性、特异性以及准确性。结果观察组孕妇的宫颈长度明显短于对照组,MMP-8水平明显高于对照组,差异均具有统计学意义(P<0.05)。宫颈长度测量联合MMP-8检测对早产的诊断敏感性、特异性、准确性分别为93.75%(30/32)、96.09%(123/128)、95.63%(153/160)。结论采用经阴道超声测量宫颈长度联合MMP-8检测对先兆早产具有较高的预测价值,有利于早产的早期诊断。
Objective To study and evaluate the value of transvaginal ultrasonography in predicting the rate of threatened preterm labor by measuring the length of cervix combined with matrix metalloproteinase-8 (MMP-8). Methods Eighty pregnant women with threatened preterm birth as the observation group and 80 normal pregnant women as the control group were given vaginal ultrasound cervical length measurement and MMP-8 test. The cervical length and the expression of MMP-8 were compared between the two groups to calculate the cervical Sensitivity, specificity, and accuracy of length measurement in combination with MMP-8 for the diagnosis of preterm birth. Results The cervical length of pregnant women in observation group was significantly shorter than that of control group, and the level of MMP-8 was significantly higher than that of control group (P <0.05). The diagnostic sensitivity, specificity and accuracy of cervical length measurement combined with MMP-8 detection for preterm birth were 93.75% (30/32), 96.09% (123/128) and 95.63% (153/160), respectively. Conclusions Transvaginal ultrasonography to measure the length of cervix combined with MMP-8 has a higher predictive value for threatened preterm birth and is beneficial for the early diagnosis of preterm birth.