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饭冢等于1975年报导,当过了易患新生儿出血症的时期后,在新生儿晚期至乳儿初期亦可遇到因维生素K缺乏引起的出血性疾病,且可伴颅内出血,此后于日本才对此病引起重视。依Bhanchet氏、冈岛氏等报导,伴颅内出血者分别为63％及41％。本病其他症状有紫癜、消化道出血、注射部位出血不止等。全部病例为母乳喂养为其特征。本文著者遇到以母乳喂养的小乳儿,因惊厥、出血现象、意识障碍等而入院的颅内出血2例和以血便、鼻衄为主诉的及有严重出血现象2例。以下仅摘录例2、例3。
Iizuka et al. Reported in 1975 that after a period of predisposition to neonatal hemorrhagic disease, hemorrhagic disease due to vitamin K deficiency may also be encountered in the late neonatal period to the early stage of infancy and may be associated with intracranial hemorrhage. Since then, Only pay attention to the disease. According to Bhanchet’s, Okazaki’s and other reports, with intracranial hemorrhage was 63% and 41%. Other symptoms of this disease are purpura, gastrointestinal bleeding, bleeding at the injection site and more. All cases are characterized by breastfeeding. In this paper, the author encountered small breast-fed babies, convulsions, bleeding, unconsciousness and other hospital admission of intracranial hemorrhage in 2 cases and bloody stools, epistaxis chief complaint and severe bleeding in 2 cases. The following extract only Example 2, Example 3.