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为了探讨术前血清Pentraxin-3、CYFRA21-1、TTF-1因素与术后早期复发的关系,收集我院胸外科行手术切除治疗的NSCLC患者103例。记录患者性别、年龄、术前血清Pentraxin-3、CYFRA21-1、TTF-1水平、临床分期、肿瘤分化程度、肿瘤直径、组织学类型及术后早期复发情况,并统计分析各因素与术后早期复发的关系。发现早期复发组的术前CYFRA21-1和TTF-1水平要明显高于未复发组,经比较两者之间的差异均具有统计学意义;临床分期、肿瘤分化程度、组织学类型与术后早期复发相关(p<0.05);TTF-1水平及临床分期、肿瘤分化程度与NSCLC术后早期复发相关;TTF-1水平设为42.38 ng/mL时,曲线下面积为0.892(p=0.000);临床分期Ⅰ期、Ⅱ期与Ⅲ期相比较,曲线下面积为0.741(p=0.001);肿瘤分化程度低、中与高相比较,曲线下面积为0.856(p=0.000)。结合我们的研究可以推论,TTF-1水平联合肿瘤分化程度及临床分期可作为NSCLC术后早期复发的标志物。
To investigate the relationship between preoperative serum Pentraxin-3, CYFRA21-1, TTF-1 and early postoperative recurrence, 103 patients with NSCLC who underwent surgical resection in our department of thoracic surgery were collected. The patients’ gender, age, preoperative serum Pentraxin-3, CYFRA21-1, TTF-1 levels, clinical stage, tumor differentiation, tumor diameter, histological type and early postoperative recurrence were recorded. Early recurrence of the relationship. The level of preoperative CYFRA21-1 and TTF-1 in the early recurrence group was significantly higher than that in the non-recurrence group. The differences between the two groups were statistically significant. The clinical stage, tumor differentiation, histological type and postoperative (P <0.05). TTF-1 level, clinical stage and tumor differentiation were correlated with early postoperative recurrence of NSCLC. The area under the curve was 0.892 (p = 0.000) when TTF-1 was 42.38 ng / ; The clinical stage Ⅰ, Ⅱ and Ⅲ compared the area under the curve was 0.741 (p = 0.001); tumor differentiation was low, and the area under the curve was 0.856 (p = 0.000). Combined with our study, we can deduce that TTF-1 level combined with tumor differentiation and clinical stage can be used as a marker of early postoperative recurrence of NSCLC.