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目的 在蛋白水平研究 IL - 1受体 I型在大鼠颈上节中的表达 .方法 免疫组织化学 ABC方法 .结果 在正常大鼠颈上节中 ,有大量 IL - 1受体 I型免疫反应阳性细胞 ,多为中、小型神经节细胞 ,也有一些小强荧光细胞 ( SIF)呈 IL- 1受体 I型阳性 . L PS免疫刺激后 ,阳性细胞的数量和染色强度无明显变化 .结论 大鼠颈上节神经元存在 IL- 1受体 ,表明周围植物性神经元能对促炎性细胞因子起反应 .本研究为免疫性细胞因子影响植物性神经元的信号活动提供了形态学基础
Objective To study the expression of IL - 1 receptor type I in the superior cervical segment of rat at the protein level.Methods ABC method was used immunohistochemically.Results There were a large number of IL - 1 receptor type I immunoreactions Positive cells, mostly in medium and small ganglion cells, there are some small strong fluorescent cells (SIF) showed IL-1 receptor type I positive.L PS immunostimulation, the number of positive cells and staining intensity did not change.Conclusion Rats The presence of IL-1 receptors in the superior ganglion neurons suggests that peripheral plant-derived neurons can respond to proinflammatory cytokines This study provides a morphological basis for the influence of immune cytokines on the signaling activity of vegetative neurons