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目的观察泮托拉唑与奥美拉唑治疗胃溃疡的临床效果和安全性。方法选取医院接受治疗的150例胃溃疡患者作为研究对象,随机分为对照组和观察组,每组75例。2组均采用常规治疗,对照组加用奥美拉唑治疗,观察组加用泮托拉唑治疗。在治疗周期结束后分别比较2组患者的临床治疗效果、胃溃疡复发率、幽门螺杆菌根除率、不良反应发生率和治疗费用。结果 2组患者不良反应发生率和总有效率比较差异无统计学意义(P>0.05);观察组胃溃疡复发率、幽门螺杆菌根除率和治疗费用均优于对照组,差异有统计学意义(P<0.05)。结论泮托拉唑与奥美拉唑对于胃溃疡患者的治疗都有一定的效果,但相比较奥美拉唑,泮托拉唑复发率更低,幽门螺杆菌根除率更高,治疗费用少,得临床上推广应用。
Objective To observe the clinical effect and safety of pantoprazole and omeprazole in the treatment of gastric ulcer. Methods A total of 150 gastric ulcer patients treated in our hospital were selected as the research object and randomly divided into control group and observation group, with 75 cases in each group. Both groups were treated with conventional therapy, the control group plus omeprazole treatment, the observation group plus pantoprazole treatment. After the end of the treatment period, the clinical outcomes, gastric ulcer recurrence rate, Helicobacter pylori eradication rate, incidence of adverse reactions and treatment costs were compared between the two groups. Results There was no significant difference in the incidence of adverse reactions and total effective rate between the two groups (P> 0.05). The recurrence rate of gastric ulcer, eradication rate of Helicobacter pylori and treatment cost in the observation group were better than those in the control group, with significant difference (P <0.05). Conclusions Pantoprazole and omeprazole have some effects on the treatment of patients with gastric ulcer. However, compared with omeprazole, the recurrence rate of pantoprazole is lower, the eradication rate of Helicobacter pylori is higher, and the treatment cost is less , Have clinical application.