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本文用抑制TxA_2合成酶的药物——苄基咪唑(BIm)和抑制血小板聚集的活血化瘀中药藏红花、毛冬青甲素和丹参对实验性原位性肾炎模型进行了干扰,结果显示BIm,藏红花和毛冬青甲素组动物的尿蛋白显著低于对照组,肾小球中的免疫复合物吸收加速,病理组织损害亦较对照组有显著的改善,尿毒症的死亡率较对照组减少。但丹参组和对照组比较则无显著性差别。结论;藏红花、毛冬青甲素和BIm对实验性原位性肾炎有治疗作用。提示血小板和TxA_2在原位性肾炎发病机理和病情发展中起着重要的致病作用。
In this article, the experimental in situ nephritis model was interfered with benzoyl imidazole (BIm), a drug that inhibits TxA2 synthase, and saffron, scopolamine, and salvia miltiorrhiza that inhibit platelet aggregation and blood circulation, and the results showed that BIm and saffron The urinary protein in the animals of the guinea pig and the Maodongqing A group was significantly lower than that of the control group. The absorption of immune complexes in the glomeruli was accelerated, and the pathological tissue damage was also significantly improved compared with the control group. The uremia mortality rate was lower than that of the control group. However, there was no significant difference between the Salvia miltiorrhiza group and the control group. Conclusion: Saffron, scopolamine and BIm have therapeutic effects on experimental in situ nephritis. It is suggested that platelet and TxA 2 play an important pathogenic role in the pathogenesis and progression of in situ nephritis.