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过去,研究者报道白细胞介素-1(IL-1)和肿瘤坏死因于(TNF)的生物学活性有许多相似之处。然而,本文作者发现,在人FS。细胞培养中,TNF可抑制脑心肌炎(EMC)病毒感染,而人IL-1α和IL-1β无此作用。另外,这两类IL-1都可抑制TNF诱导的抗病毒状态。为了阐明其机理,研究了IL-1对由Poly I.C诱导β干扰素(IFN-β)的影响。作者发现,在以Poly I.C诱导前2～6小时加入IL-1,可明显抑制IFN-β的合成,在最适条件下,IL-1α 10pg/ml或IL-1β100pg/ml足以使IFN的合成几乎达到最大
In the past, researchers reported that there are many similarities between interleukin-1 (IL-1) and tumor necrosis due to the biological activity of (TNF). However, the author of this article found that in people FS. In cell culture, TNF inhibits encephalomyocarditis (EMC) virus infection, whereas human IL-1α and IL-1β do not. In addition, both types of IL-1 inhibit TNF-induced antiviral status. To elucidate its mechanism, the effect of IL-1 on the induction of interferon beta (IFN-β) by Poly I.C. was studied. The authors found that the addition of IL-1 2 to 6 hours prior to induction with Poly IC significantly inhibited the synthesis of IFN-β, under optimal conditions, IL-1α 10 pg / ml or IL-1 β 100 pg / ml was sufficient for IFN synthesis Almost reached the maximum