论文部分内容阅读
目的:研究绝经前乳腺癌患者术后辅助化疗对月经的影响。方法:回顾性研究144例绝经前乳腺癌患者化疗后出现闭经的比例、时间以及月经恢复的比例和时间。其中78例接受FEC方案,66例接受TE方案。分析患者的临床特征与化疗致闭经(CIA)及月经恢复的相关性。结果:126例(87.5%)患者出现CIA,其中107例(84.9%)停经出现在前3个疗程后;≤40岁患者CIA的发生率显著低于>40岁的患者(P<0.05),化疗方案及激素受体状态对发生率无统计学差异(P>0.05)。126例出现CIA的患者中共有74例(58.7%)恢复月经,中位时间为化疗结束后5个月;年龄及激素受体状态对CIA的恢复有统计学差异(P<0.05)。结论:年龄是预测CIA出现和月经恢复的指标。激素受体阳性患者服用三苯氧胺对月经恢复有显著影响。
Objective: To study the effect of postoperative adjuvant chemotherapy on menstruation in premenopausal women with breast cancer. Methods: A retrospective study of 144 patients with premenopausal breast cancer after chemotherapy, the proportion of amenorrhea, time and the proportion of menstruation and recovery time. Of these, 78 received FEC and 66 received TE. To analyze the clinical characteristics of patients with chemotherapy induced amenorrhea (CIA) and menstrual recovery correlation. Results: Of the 126 patients (87.5%), CIA occurred in 107 patients (84.9%) after the first three courses of treatment. The incidence of CIA in patients ≤40 years old was significantly lower than that of patients> 40 years old (P <0.05) There was no significant difference in the incidence of chemotherapy regimen and hormone receptor status (P> 0.05). Of the 126 patients with CIA, 74 (58.7%) recovered to menstruation with a median time of 5 months after the end of chemotherapy. There was a significant difference in age and hormone receptor status (P <0.05). Conclusion: Age is a predictor of CIA emergence and menstrual recovery. Hormone receptor-positive patients taking tamoxifen have a significant effect on menstrual recovery.