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目的 评价南方食管癌高发区和低发区人群总N 亚硝基化合物 (TNOC)的接触水平。方法 在食管癌高发区南澳县和低发区陆丰县各随机选择 12 0名 35～ 6 4岁男性 ,采用双份饭法收集2 4h膳食和 12h尿液 ,测定TNOC、非挥发性亚硝胺和挥发性亚硝胺。结果 高发区膳食TNOC检出率(95 % )、膳食TNOC日摄入量 [(4 2 5± 0 84 ) μmol/d]和尿 12h排出量 [(1 76± 0 2 3)ng/ 12h]、膳食挥发性亚硝胺日摄入量 [(2 6 6± 31 2 ) μg/d]均高于低发区。食管癌死亡率分别与膳食TNOC日摄入量和尿TNOC排泄量呈等级正相关关系。尿非挥发性亚硝胺排泄量两地无差异。结论 南方食管癌高发区人群TNOC的接触水平明显高于低发区人群
Objective To evaluate the exposure of total N-nitroso compounds (TNOCs) in high incidence and low incidence areas of esophageal cancer in the south. Methods A total of 120 males aged 35 to 64 years were randomly selected from Nan’ao County in the high incidence area of esophageal cancer and Lufeng County in the low incidence area. The serums of 24 h and 12 h were collected by double serving method. The contents of TNOC, nonvolatile nitrosamine And volatile nitrosamines. Results The TNOC detection rate (95%), dietary TNOC intake [(4 2 5 ± 0 84) μmol / d] and urinary 12h excretion [(1 76 ± 0 2 3) ng / 12h] , Daily intake of dietary volatile nitrosamines [(266 ± 31 2) μg / d] were higher than those in the low incidence areas. The mortality of esophageal cancer was positively correlated with dietary TNOC daily intake and urine TNOC excretion. Urinary non-volatile nitrosamine excretion no difference between the two places. Conclusions The contact level of TNOC in the population with high incidence of esophageal cancer in South China is obviously higher than that in low incidence areas