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为探讨孕妇巨细胞病毒、弓形虫感染率和胎儿传播率以及与胎儿畸形的关系，随机选择２０００例不同职业孕妇，采用ＰＣＲ技术对其外周血及配对胎儿脐血进行ＣＭＶ、弓形虫检测。结果：孕妇ＣＭＶ阳性率４．０５％（８１／２０００），弓形虫阳性率２．１５％（４３／２０００），配对脐血ＣＭＶ阳性率１％（２０／２０００），弓形虫阳性率０．７％，母婴传播率分别为２０／８１，１４／４３。具有异常妊娠史孕妇ＣＭＶ感染率１２．３％（３５／２８３），弓形虫感染率７．０７％（２０／２８３），与无异常妊娠史孕妇（２．６８％，４６／１７１７）；（１．３４％，２３／１７１７）比较，差异显著（Ｐ＜０．０１）。１２４例ＣＭＶ、弓形虫感染孕妇发生胎儿畸形７例（５．６４％），无感染１８７６例孕妇发生胎儿畸形４８例（２．５６％），两组比较差异显著（Ｐ＜０．０５）。本研究表明：开展对孕妇ＣＭＶ、弓形虫感染检测，进行早期诊断，有利于优生优育工作。
To explore the relationship between maternal cytomegalovirus, Toxoplasma gondii infection rate, fetal transmission rate and fetal malformation, a total of 2000 pregnant women of different occupations were randomly selected. CMV and Toxoplasma gondii were detected by PCR in peripheral blood and matched umbilical cord blood. Results: The positive rate of CMV in pregnant women was 4.05% (81/2000), the positive rate of Toxoplasma gondii was 2.15% (43/2000), the positive rate of CMV in matched cord blood was 1% (20/2000), and the positive rate of Toxoplasma gondii was 0. 7%, mother-to-child transmission rates were 20/81, 14/43 respectively. The pregnant women with abnormal pregnancy history had a positive rate of CMV infection of 12.3% (35/283), Toxoplasma gondii infection rate of 7.07% (20/283) and pregnant women without abnormal pregnancy history (2.68%, 46/1717) 1.34%, 23/1717), the difference was significant (P <0.01). Among 124 pregnant women with CMV and Toxoplasma infection, 7 cases (5.64%) had fetal malformations, and 48 cases (2.56%) had fetal malformations with 1876 pregnant women without infection. There were significant differences between the two groups (P <0.05). This study shows that: To carry out the detection of pregnant women CMV, Toxoplasma gondii infection, early diagnosis, is conducive to the work of prenatal and postnatal care.