论文部分内容阅读
目的探讨血清前白蛋白(PA)水平对评估慢加急性肝衰竭(ACLF)患者预后的意义。方法检测57例存活ACLF患者(存活组)、67例死亡ACLF患者(死亡组)和65例健康体检者(对照组)血清PA水平,分析死亡组患者在ACLF终末期血清PA的动态变化。结果存活组与死亡组血清PA水平均明显低于对照组[(156.23±33.74)mg/L和(117.14±23.36)mg/L vs.(337.54±50.72)mg/L](P<0.05)。死亡组血清PA水平逐渐降低至临终前1-5d的(36.13±9.64)mg/L。结论血清PA进行性下降可能提示ACLF预后不佳。
Objective To investigate the significance of serum prealbumin (PA) level in assessing the prognosis of patients with acute and chronic hepatic failure (ACLF). Methods The serum levels of PA in 57 survivors with ACLF (survivors), 67 patients with ACLF (death group) and 65 healthy controls (control group) were measured. The changes of serum PA in the patients with death after ACLF were analyzed. Results Serum PA levels in survivors and death patients were significantly lower than those in the control group [(156.23 ± 33.74) mg / L and (117.14 ± 23.36) mg / L vs. (337.54 ± 50.72) mg / L], respectively. Serum PA levels in the death group gradually decreased to (36.13 ± 9.64) mg / L 1-5 d before dying. Conclusions The progressive decline of serum PA may indicate poor prognosis of ACLF.