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HI-6是迄今双吡啶肟类中抗梭曼效果较好的药物,它主要的作用是使梭曼抑制的乙酰胆碱酯酶(ACHE)早期重活化。但是Wolthuis等研究HI-6对大鼠、豚鼠、狗及人离体肋间肌梭曼中毒肌接头传递功能的恢复作用中,提出:HI-6对上述三种动物肌肉的梭曼中毒都有对抗作用,而对人的肌肉仅能对抗沙林而不能对抗梭曼;经Smith等的分析,认为HI-6不能重活化人体肌肉中梭曼抑制的AChE,仅见到肌接头传递功能的适应性恢复。本研究的目的是比较不同种属哺乳动物呼吸肌终板的梭曼中毒酶被HI-6重活化作用的差别,试图说明HI-6对人体组织中梭曼抑制的AChE重活化作用的特点。
HI-6 is the anti-soman effect so far in bipyridine oximes. Its main function is to early reactivate soman-inhibited acetylcholinesterase (ACHE). However, Wolthuis and so on HI-6 rats, guinea pigs, dogs and human intercostal muscle soman intoxication muscle connector transmission function recovery, proposed: HI-6 on the above three animal muscle Soman poisoning has Confrontation, while the human muscle can only combat sarin and can not combat the soman; According to Smith et al., It is believed that HI-6 can not reactivate soman-inhibited AChE in human muscle and only sees the adaptability of the muscular adapter transmission function restore. The purpose of this study was to compare the differences in the HI-6 reactivation of soman toxin from respiratory muscle endplates of different species in an attempt to elucidate the effect of HI-6 on soman-inhibited AChE reactivation in human tissues.