研究背景大多数手术操作均可引起术后疼痛。术后疼痛属于损伤性疼痛,若处理不当可引起多种严重并发症。尽管近年来术后疼痛发病机制及治疗方法取得较大进展,但是对临床医生而言如何有效预防和控制术后疼痛仍是一个挑战。大量文献证明,丝裂原活化蛋白激酶(mitogen-activated protein kinase,MAPK)信号通路和白细胞介素1β(interleukin-1,IL-1β)可介导多种病理性疼痛
The cellular prion protein (PrPC) expression was analyzed by western-blot in the rat, in two different dimorphic brain areas such as the anterior hypothalamic a
The mechanisms underlying the secondary or delayed cell death in the hippocampus and cerebral hemisphere after traumatic brain injury (TBI) have been poorly und