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目的:探讨安伸补气丸抗抑郁作用机制。方法:将慢性应激抑郁模型大鼠随机分为6组,中药高、中、低剂量组分别予以1 mL中药灌胃,氟西汀组以2 mg/kg给药,正常组及模型组予以1 mL生理盐水灌胃,1次/d,给药21 d;高校液相色谱法检测大鼠大脑皮层单胺类神经递质的含量,同时考察安神补气丸对大鼠行为学的影响。结果:安神补气丸高中低剂量组都能降低大鼠大脑皮层DA、5-HT、NE的含量(P<0.01),同时提高大鼠的食欲、体质量及活动性。结论:安神补气丸具有一定的抗抑郁作用。
Objective: To investigate the antidepressant mechanism of “Anxu Buqi Pills”. Methods: Chronic stress depression model rats were randomly divided into 6 groups, high, medium and low dose groups were given 1 mL of Chinese medicine, fluoxetine group at 2 mg / kg, normal group and model group 1 mL saline, once a day for 21 days. The contents of monoamine neurotransmitters in the cerebral cortex of rats were detected by high performance liquid chromatography, and the effect of Anshen Buqi Pill on the behavior of rats was also investigated. Results: Both Anshin Buqi Pill group and high, middle and low dose groups could decrease the contents of DA, 5-HT and NE (P <0.01) and increase the appetite, body weight and activity in rats. Conclusion: Anshen Buqi pill has some antidepressant effect.