论文部分内容阅读
目的:探讨溴隐亭治疗泌乳素大腺瘤的方法、效果及不良反应。方法:回顾性分析单纯溴隐亭治疗9例泌乳素大腺瘤的长期随访结果。结果:溴隐亭的开始剂量为1.25～2.5 mg.d-1、分2～3次口服,在6个月内缓慢增至5～15 mg.d-1。平均随访58.3个月,最后随访时血泌乳素(prolactine,PRL)恢复正常8例(88.89%)、肿瘤体积平均缩小(81.3±23.9)%。治疗期间大部分原发症状好转,出现头晕2例、脑脊液漏1例。结论:溴隐亭单药治疗泌乳素大腺瘤能明显降低血PRL、缩小肿瘤体积及改善临床症状,且不良反应少。
Objective: To investigate the method, effect and adverse reaction of bromocriptine in treatment of prolactinoma. Methods: The long-term follow-up results of 9 cases of prolactinoma adenoma treated with bromocriptine alone were retrospectively analyzed. Results: The initial dose of bromocriptine was 1.25-2.5 mg.d-1 orally in 2 to 3 doses and slowly increased to 5 to 15 mg.d-1 in 6 months. After a mean follow-up of 58.3 months, 8 cases (88.89%) returned to normal with prolactine (PRL) at the final follow-up and the tumor volume was reduced by an average of 81.3 ± 23.9%. During the treatment of most of the primary symptoms improved, there were 2 cases of dizziness, cerebrospinal fluid leakage in 1 case. Conclusion: Bromocriptine treatment of prolactin large adenoma can significantly reduce blood PRL, reduce tumor size and improve clinical symptoms, and less adverse reactions.