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目的探讨体外受精-胚胎移植(in vitro fertilization-embryo transfer,IVF-ET)过程中胚移植后4天血清孕激素(progesterone,P)与IVF-ET结局的关系。方法将研究对象根据妊娠结局分为妊娠组和非妊娠组,比较两组P差异;将研究对象根据P值分成3组(A组:P<50nmol/L,B组:50nmol/L120nmol/L)分析3组间着床率、临床妊娠率、早期自然流产率差异。结果妊娠组与非妊娠组P差异无统计学意义(P>0.05),三组间着床率、临床妊娠率差异无统计学意义(P>0.05),B组早期自然流产率较A组和C组显著下降,差异有统计学意义(P<0.05)。结论胚胎移植后4天血清P水平与临床妊娠率无显著相关性,但P在50-120nmol/L之间早期自然流产率最低。
Objective To investigate the relationship between serum progesterone (P) and IVF-ET outcome 4 days after embryo transfer during in vitro fertilization-embryo transfer (IVF-ET). Methods The subjects were divided into pregnancy group and non-pregnancy group according to the outcome of pregnancy. The differences of P between the two groups were compared. The subjects were divided into 3 groups according to P value (group A: P <50nmol / L, group B: 50nmol / L < 120nmol / L, C group: P> 120nmol / L) were used to analyze the difference of implantation rate, clinical pregnancy rate and early spontaneous abortion rate among the three groups. Results There was no significant difference in P between pregnancy group and non-pregnancy group (P> 0.05). There was no significant difference in implantation rate and clinical pregnancy rate among the three groups (P> 0.05) C group decreased significantly, the difference was statistically significant (P <0.05). Conclusion There was no significant correlation between serum P level and clinical pregnancy rate 4 days after embryo transfer. However, the early spontaneous abortion rate was the lowest between 50-120 nmol / L.