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3,4’,5-三羟基芪-3-β-单-D-葡萄糖甙(PD)0.33,0.56,0.95,1.63,2.79mmol·L~1能显著抑制2.3mmol·L~1·s~1凝血酶诱导的家兔洗涤血小板聚集,呈良好的量效关系,PD对1 min和最大血小板聚集抑制率IC_(50)分别为0.57和1.16 mmol·L~1,并能使血小板聚集延迟相延长,血小板聚集速度减慢,PD0.33～1.63mmol·L~1对血小板聚集时TXA_2释放无明显影响,仅在浓度为2.79mmol·L~1时,才明显减少TXA_2释放,PD的作用与阿司匹林不完全相同.这可能与它们的作用机理不同有关,本文还观察了PD0.33 mmol·L~1有抑制凝血酶诱导兔血小板胞浆游离钙离子浓度升高的作用。
(PD) 0.33,0.56,0.95,1.63,2.79mmol·L -1 can significantly inhibit 2.3mmol · L ~ 1 · s ~ 1 thrombin-induced rabbit platelet aggregation, showed a good dose-effect relationship. The IC 50 of PD for 1 min and maximal platelet aggregation were 0.57 and 1.16 mmol·L -1, respectively, and the platelet aggregation delayed phase PD0.33 ~ 1.63mmol·L ~ 1 had no significant effect on the release of TXA2 when platelet aggregation, only when the concentration was 2.79mmol·L ~ 1, the release of TXA_2 was significantly reduced. The effect of PD Aspirin is not exactly the same, which may be related to their different mechanism of action, this paper also observed PD0.33 mmol·L -1 inhibit thrombin-induced platelet cytosolic free calcium ion concentration.