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目的考察卵巢良性、交界性和恶性组织的SDF-1和CXCR4的表达及临床意义。方法收集2012年4月-2015年2月行手术切除的卵巢组织标本106份,其中卵巢恶性肿瘤34份、卵巢交界性肿瘤35份和卵巢良性肿瘤37份。结果光镜下SDF-1、CXCR4在胞浆内呈黄褐色或棕黄色颗粒。与卵巢恶性肿瘤组比,卵巢交界性肿瘤的SDF-1与CXCR4表达较低(P<0.05),卵巢良性肿瘤组无SDF-1与CXCR4表达。SDF-1与CXCR4的表达在卵巢恶性肿瘤的临床分期、病理分级、化疗效果和淋巴结转移方面存在统计学差异(P<0.05),但在不同年龄和残存瘤灶无统计学差异(P>0.05)。结论在SDF-1与CXCR4的作用下,卵巢癌的增殖、侵袭、转移等能力增加。
Objective To investigate the expression and clinical significance of SDF-1 and CXCR4 in benign, borderline and malignant ovarian tissues. Methods From April 2012 to February 2015, 106 patients with surgically resected ovarian tissues were collected, including 34 ovarian malignant tumors, 35 ovarian border tumors and 37 ovarian benign tumors. Results Under the light microscope, SDF-1 and CXCR4 were yellow-brown or brown granules in the cytoplasm. Compared with ovarian malignant tumor group, the expression of SDF-1 and CXCR4 in ovarian borderline tumor was lower (P <0.05), and no expression of SDF-1 and CXCR4 in benign ovarian tumor group. The expression of SDF-1 and CXCR4 in ovarian cancer clinical stage, pathological grade, chemotherapy effect and lymph node metastasis statistical difference (P <0.05), but in different age and residual tumor no significant difference (P> 0.05 ). Conclusion Under the action of SDF-1 and CXCR4, the ability of proliferation, invasion and metastasis of ovarian cancer is increased.