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本文采用已预先纯化的SD大鼠的前列腺组织蛋白 ,所用剂量分别为低 (0 .1mg/只 )、中 (0 .3mg/只 )和高剂量 (0 .5和 1mg/只 )三种 ,多点皮下注射 ,同时腹腔注射福氏完全佐剂 (CFA)和百白破疫苗 ,造模时间分别为 6周和 8周。观察实验小鼠大体形态表现如膀胱充盈、前列腺湿重和前列腺组织的病理学改变。结果表明 :(1)造模6周的小鼠 ,仅有高剂量组产生急性炎症表现。 (2 )造模 8周时 ,可见高剂量组小鼠出现不同程度的慢性炎症和增生病理变化。作者认为本研究运用免疫佐剂法初步建立了慢性非细菌性前列腺炎的小鼠模型 ,为进一步研究该病的发病机制和寻找有效治疗的新药提供实验方法
In this paper, prostatic tissue protein of pre-purified SD rats were used in this study. The dosages were low (0.1 mg / body), medium (0.3 mg / body) and high dose (0.5 and 1 mg / body) More subcutaneous injection, intraperitoneal injection of Freund’s complete adjuvant (CFA) and diphtheriae vaccine, modeling time were 6 weeks and 8 weeks. Observe the general morphology of experimental mice such as bladder filling, wet weight of prostate and pathological changes of prostate tissue. The results showed that: (1) mice at 6 weeks of modeling had only acute inflammatory manifestations in the high-dose group. (2) At 8 weeks, the mice in high dose group showed different degrees of chronic inflammation and hyperplasia pathological changes. The author believes that this study established a model of chronic non-bacterial prostatitis by immunoadjuvant method in order to provide experimental methods for further study of the pathogenesis of the disease and find new drugs for effective treatment