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作者对24例经组织病理证明为不同苔藓样皮肤病患者的皮肤潘检标本进行了免疫组织学研究。其中包括扁平苔藓(LP)、光泽苔藓(LN)、苔藓样药疹(LDE)、DLE、SLE、固定性药疹(FDE)、苔藓样糠疹(PL)和多形红斑(EM)。对照标本选用无任何向表皮性证据的患者如结节性红斑。用单克隆抗体(抗Leu 2、Leu3、HLA-DR 和OKT6、S100)按免疫过氧化物酶染色法对冰冻切片进行检查。结果发现,苔藓样皮肤病的皮肤淋巴样浸润以辅助/诱导性表型(CD4(?))的T 细胞为主。少数病例以细胞毒/抑制性表型(CD8(?))T 细胞为主。向表皮的T 细胞也表现为
The authors performed immunohistochemical studies on the skin biopsy specimens of 24 patients with histopathologic evidence of different bryodermatosis. These include lichen planus (LP), glossy lichen (LN), lichenoid eczema (LDE), DLE, SLE, fixed drug eruption (FDE), lichenoid herpes (PL), and erythema multiforme (EM). Control specimens were selected for patients with no evidence of epidermis such as nodular erythema. Frozen sections were examined by immunoperoxidase staining with monoclonal antibodies (anti-Leu 2, Leu3, HLA-DR and OKT6, S100). It was found that lymphoid infiltration of the skin of moss-like dermatosis was predominantly T-cells with a helper/inducible phenotype (CD4(?)). A few cases are dominated by cytotoxic/inhibitory phenotype (CD8(?)) T cells. T-cells to the epidermis also appear to be