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目的 探讨自制阿霉素控释剂在体内、外释药效果及对大鼠C6胶质瘤动物模型的治疗作用。方法 应用荧光光谱法检测阿霉素控制剂在人工脑脊液及 18只正常家兔脑内药物释放的情况 ;检测阿霉素控释剂对 10只脑内荷瘤SD大鼠生存期的影响以及不同给药方式 (局部或腹腔给药 )对 30只SD大鼠皮下接种肿瘤生长的抑制作用。结果 阿霉素控释剂在人工脑脊液和兔脑内可持续释放达 10d以上 ;局部控释化疗可明显延长脑内荷瘤大鼠的生存期 ,实验组中位生存时间为 31d。局部阿霉素控释化疗对于皮下肿瘤有明显抑制效应 ,与腹腔注射等量阿霉素化疗组相比 ,差异有非常显著性 (P <0 .0 1)。结论 控释化疗在避免系统化疗全身毒性的同时 ,增加肿瘤局部药物浓度 ,可有效抑制肿瘤生长
Objective To investigate the therapeutic effect of self-made doxorubicin controlled release in vivo and in vitro and in the treatment of rat C6 glioma animal model. Methods Fluorescence spectrometry was used to detect the release of doxorubicin in artificial cerebrospinal fluid and eighteen normal rabbits. The effects of doxorubicin on the survival of 10 SD rats were detected Administration of the drug (topical or intraperitoneal administration) suppresses tumor growth in subcutaneously inoculated 30 SD rats. The results of sustained release of doxorubicin controlled release in artificial cerebrospinal fluid and rabbit brain for more than 10d; local controlled release chemotherapy can significantly prolong the survival of brain tumor-bearing rats, the median survival time of the experimental group was 31d. Local doxorubicin controlled-release chemotherapy for subcutaneous tumors have a significant inhibitory effect, and intraperitoneal injection of an equivalent dose of doxorubicin chemotherapy group, the difference was significant (P <0. Conclusion Controlled-release chemotherapy can reduce the systemic toxicity of systemic chemotherapy and increase the concentration of local drug in the tumor, which can effectively inhibit tumor growth