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目的探讨血管紧张素Ⅱ(angiotensinⅡ,AngⅡ)及血管紧张素ⅡⅠ型受体(angiotensinⅡ type Ⅰ receptor,AT1R)在人肝细胞癌组织中的表达及其与肝癌临床病理特征的关系。方法应用免疫组织化学方法分析行手术切除的45例肝癌和癌旁组织以及12例正常肝组织的AngⅡ及AT1R的表达情况。结果45例肝癌组织中39例AngⅡ表达阳性(86.67%),41例AT1R表达阳性(91.11%);45例癌旁组织中7例AngⅡ表达阳性(15.56%),10例AT1R表达阳性(22.22%)。正常肝组织标本AngⅡ及AT1R表达均阴性。AngⅡ及AT1R在肝癌组织中的表达与患者的性别、年龄、肿瘤直径、Hb-sAg(+/-)、AFP和肝硬化背景无关(P>0.05),临床分期高及病理分级高两者的表达显著性高于分期低及分级低者(P<0.01)。结论AngⅡ及AT1R在肝癌组织中的表达升高,并且随肝癌的分期及病理分级表达增高,表明AngⅡ及AT1R与肝癌的发生、发展及转移有关。
Objective To investigate the expression of angiotensin Ⅱ (AngⅡ) and angiotensin Ⅱ type Ⅰ receptor (AT1R) in human hepatocellular carcinoma (HCC) and its relationship with clinicopathological features. Methods Immunohistochemistry was used to analyze the expression of Ang Ⅱ and AT1R in 45 cases of hepatocellular carcinoma and adjacent normal tissues and 12 cases of normal liver tissues. Results The positive expression of AngⅡ was found in 39 cases (86.67%) and the expression of AT1R in 41 cases (91.11%) in 45 cases of hepatocellular carcinoma. The positive expression of AngⅡ in 7 of 45 cases (15.56%) and the expression of AT1R in 22 cases ). The expression of Ang Ⅱ and AT1R in normal liver tissue were negative. The expression of AngⅡ and AT1R in hepatocellular carcinoma was not related to the patient’s gender, age, tumor diameter, Hb-sAg (+/-), AFP and cirrhosis (P> 0.05), high clinical stage and high histological grade Significantly higher expression than staging low and low grade (P <0.01). Conclusions The expression of AngⅡ and AT1R in HCC tissue is increased, and with the increase of staging and pathological grade of HCC, AngⅡ and AT1R are associated with the occurrence, development and metastasis of HCC.