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目的分析康艾注射液联合化疗和单纯化疗治疗老年非小细胞肺癌的疗效及不良反应。方法将56例老年患者随机分成两组。单纯化疗组(对照组)28例采用吉西他滨(国产)1000mg/m2,第1、8天,顺铂25mg/m2第1～4天;联合化疗组(观察组)28例采用方案及剂量同对照组,同时,化疗开始即联合应用康艾注射液,即康艾注射液60ml+5%葡萄糖液250ml,静脉滴注,连续10d,21d为一周期,至少治疗2周期。结果观察组有效率为12/28(42.8%),对照组有效率为9/28(32.1%),差异无统计学意义(P>0.05);观察组不良反应发生率、程度及生活质量均优于对照组。结论康艾注射液联合化疗可减少老年非小细胞肺癌患者不良反应发生率,减轻不良反应程度,提高患者的耐受性,从而改善老年患者生存质量、延长生命,具有一定临床意义。
Objective To analyze the curative effect and adverse reactions of Kangai injection combined with chemotherapy and chemotherapy alone in the treatment of elderly non-small cell lung cancer. Methods 56 elderly patients were randomly divided into two groups. 28 cases in the chemotherapy alone group (control group) received gemcitabine (domestic) 1000mg / m2, on the 1st and the 18th day, cisplatin 25mg / m2 on the 1st to 4th day; combined chemotherapy group (observation group) 28 cases using the protocol and dose with the control At the same time, the combination chemotherapy Kangai injection, that is, Kang Ai injection 60ml + 5% glucose solution 250ml, intravenous infusion, continuous 10d, 21d for a period of at least 2 cycles. Results The effective rate was 12/28 (42.8%) in the observation group and 9/28 (32.1%) in the control group, with no significant difference (P> 0.05). The incidence, degree and quality of life of the adverse reactions in the observation group Better than the control group. Conclusions Kangai injection combined with chemotherapy can reduce the incidence of adverse reactions, reduce the degree of adverse reactions, improve patient tolerance, improve the quality of life and prolong life in elderly patients with non-small cell lung cancer. It is of clinical significance.