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目的观察长托宁替代阿托品治疗急性有机磷农药中毒(AOPP)的临床疗效。方法急性有机磷农药中毒患者随机分为长托宁治疗组及阿托品对照组各15例,治疗组采用长托宁治疗,对照组采用传统方法阿托品治疗,对两组患者进行比较,观察长托宁用量、昏迷时间、病死率、住院时间及并发症发生率。结果与对照组比较,治疗组神志恢复时间、昏迷时间、机械通气时间、并发症发生率和病死率明显降低(P<0.05),治愈率明显升高(P<0.05)。结论长托宁疗效确实、可靠,是替代阿托品救治有机磷农药中毒的理想药物。
Objective To observe the clinical efficacy of penehyclidine hydrochloride in the treatment of acute organophosphorus pesticide poisoning (AOPP). Methods Acute organophosphorus pesticide poisoning patients were randomly divided into two groups: the control group and the control group. The control group was treated with penehyclidine and the control group was treated with atropine. The patients in the two groups were compared and observed. Dosage, coma time, fatality rate, length of hospital stay and complication rate. Results Compared with the control group, the recovery time, coma time, duration of mechanical ventilation, complication rate and mortality in the treatment group were significantly decreased (P <0.05), and the cure rate was significantly increased (P <0.05). Conclusion The long-acting effect is reliable, it is an ideal substitute for atropine for organophosphorus pesticide poisoning.