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目的:研究绝经期雌鼠舌背黏膜细胞角蛋白(CK)的变化。方法:采用免疫组织化学SABC法分别检测15只去卵巢大鼠和15只正常大鼠舌背黏膜中细胞角蛋白的表达部位和表达强度。结果:CK10与CK13在正常组与去卵巢组大鼠舌背黏膜基底上层都有表达,但在去卵巢组其表达明显高于对照组。结论:CK10与CK13的表达上调与雌鼠的雌激素水平下降有关。
Objective: To study the changes of keratin (CK) in tongue mucosa of postmenopausal women. Methods: The expression of cytokeratin in tongue back mucosa of 15 ovariectomized rats and 15 normal rats were detected by immunohistochemical SABC method. Results: The expressions of CK10 and CK13 in the basal lamina of tongue back of rats in both normal and ovariectomized groups were significantly higher than those in control group. Conclusion: The up-regulation of CK10 and CK13 is related to the decrease of female estrogen.