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为了研究丙型肝炎的发病机理应用原位杂交和免疫级化方法检测了38例慢性肝炎患者肝内HCV－RNA和HCV、NS3。11例丙型肝炎患者肝细胞中8例HCV－RNA阳性，6例HCV、NS3阳性；17例乙、丙肝重叠感染者7例阳性；10例慢性乙肝患者中求发现阳性结果。肝内HCV－RNA和HCV、NS3阳性与否同肝组织学病理改变的严重性无关。结果表明HCV可能无直接致病作用。
In order to study the pathogenesis of hepatitis C, HCV-RNA and HCV in 38 patients with chronic hepatitis were detected by in situ hybridization and immunostaining. HCV-RNA was positive in 8 patients with HCV in NS3.11 patients with hepatitis C, 6 cases of HCV, NS3 positive; 17 cases of hepatitis B and hepatitis C overlap infection in 7 cases positive; 10 cases of chronic hepatitis B and find positive results. Intrahepatic HCV-RNA and HCV, NS3-positive or not with the severity of liver histopathology has nothing to do. The results show that HCV may not have a direct pathogenic role.