为明确Vater壶腹部肿瘤中p53蛋白表达的范围,了解p53蛋白表达与肿瘤分期的关系及Vater壶腹部肿瘤活检呈假阴性的标本中是否有p53蛋白表达,作者对休斯敦三所医院病理科1983～1992年期间Vater壶腹部肿瘤的档案材料进行了研究。所有组织均为福尔马林液固定,石蜡包埋;其中癌17例,腺瘤5例,4例形态学正常的Vater壶腹标本作对照,此外还有9例壶腹部肿瘤初次 To clarify the range of p53 protein expression in Vater’s ampullary tumors, to understand the relationship between p53 protein expression and tumor stage, and whether there was p53 protein expression in Vater’s ampullary tumor biopsy specimens that were false-negative. The authors studied the pathology of the three hospitals in Houston. The archival material of Vater’s ampulla tumors was studied during 1992. All tissues were formalin-fixed and paraffin-embedded; 17 of them were cancers, 5 were adenomas, 4 Vater ampulla specimens with normal morphology were used as controls, and there were 9 cases of ampulla tumors for the first time.