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本实验采用固定比率为1:1的4h连续自身给药实验模型,药物是经典的具有较强精神依赖性的盐酸吗啡。在低于形成身体依赖性的阈下剂量,大白鼠经过一定的训练后能形成主动的觅药行为。改变每次响应注射剂量后,大白鼠均能通过调整踏板次数来控制药物的摄入量,组间t检验踏板次数有显著性差异,而日剂量无明显差异,说明精神依赖性已经形成。大白鼠自身给药实验形成稳定模型的周期短,且药物进入大鼠静脉时不延期、不打扰动物,给药的剂量准确,影响因素少,所得到的实验结果稳定可靠。
In this experiment, a continuous 4h self-administered experimental model with a fixed ratio of 1: 1 was used. The drug is a classic morphine with strong psychic dependence. Below the subthreshold dose that forms the body dependency, the rats develop proactive drug-seeking behavior after a certain amount of training. After changing the injection dose, rats can control the intake of drugs by adjusting the number of pedals. There is a significant difference in the number of pedals between groups, but the daily dose has no significant difference, indicating that the mental dependence has been formed. The short period of the rats’ self-administration experiment to form a stable model is short, and the drug enters the vein of the rat without delay and does not disturb the animal. The dosage is accurate and the influence factors are few. The experimental results obtained are stable and reliable.