Hollow silica reinforced magnesium nanocomposites with enhanced mechanical and biological properties

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INTRODUCTIONrnBioresorbable metals are a class of path-breaking biomaterials that have reshaped the nature of metallic biomaterials from bioinert regime to bioactive regime and multi-bio functional (anti-bacterial, anti-proliferation, and anti-cancer) regime1. Encouraged by this development, in recent years, magnesium (Mg)-based alloys have been extensively researched for orthopedic and maxillofacial osteosynthesis1–9. Magnesium has the advantage of being biocompatible and bioresorbable within the human body when compared with currently used permanent osteosynthesis systems manufactured from titanium alloys1. Using a biodegrad-able metal-like magnesium avoids further surgical intervention to remove the implants after desirable bone regeneration, thereby reducing the associated expenses and risk of further surgical complications. The key feature of magnesium compared with its counterpart metals is that magnesium has a similar elastic modulus (40–45 GPa) to the cortical bone (~15–30 GPa) and this reduces the stress shielding effect owing to the mismatch in elastic modulus between the cortical bone and the implant10–12.
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