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目的：探讨不同压力对兔坐骨神经内离子含量的变化及其病理改变的关系。方法：用特制的气囊压迫装置，对３５条兔坐骨神经进行急性压迫实验。压力分别为０、４、８、１２ｋＰａ（０、３０、６０、９０ｍｍＨｇ），持续加压１小时，术后一周取受压神经段，行病理形态学观察和原子吸收分光法进行离子定量分析。结果：受压神经段内Ｋ、Ｎａ、Ｃａ离子的含量明显高于对照组（Ｐ＜０．０１）。不同压力下受压神经段均发生节段性脱髓鞘改变。随压力增加受压神经段内离子含量进一步升高，脱髓鞘改变进一步加重。结论：受压神经段内钙离子增高可能加重神经组织继发性损害。周围神经嵌压后的病理变化与其电解质分布异常可能相互影响。
Objective: To investigate the relationship between the changes of ion content in sciatic nerve and pathological changes in rabbits under different pressures. Methods: Using a special balloon compression device, 35 rabbits sciatic nerve acute compression test. Pressure were 0,4,8,12 kPa (0,30,60,90 mmHg), continued to pressurize for 1 hour, one week after surgery to take the compression nerve segments, pathological morphological observation and atomic absorption spectrometry for quantitative analysis of ions. Results: The contents of K, Na and Ca in the compression nerve segment were significantly higher than those in the control group (P <0.01). Compressive segmental demyelination occurred under different pressures. With the increase of pressure, the content of ion in nerve segment increased further and the demyelination changed further. Conclusion: Increased calcium in the compression nerve segment may aggravate the secondary damage of nerve tissue. Peripheral nerve entrapment after the pathological changes and the abnormal distribution of electrolytes may affect each other.