【摘 要】
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In the ifght against cancer, controlled drug delivery systems have emerged to enhance the therapeutic effcacy and safety of anti-cancer drugs. Among these syste
【机 构】
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State Key Laboratory of Natural Medicines,CAS Key Laboratory for Biological Effects of Nanomaterials
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In the ifght against cancer, controlled drug delivery systems have emerged to enhance the therapeutic effcacy and safety of anti-cancer drugs. Among these systems, mesoporous silica nanoparticles (MSNs) with a functional surface possess obvious advantages and were thus rapidly developed for cancer treatment. Many stimuli-responsive materials, such as nanoparticles, polymers, and inorganic materials, have been applied as caps and gatekeepers to control drug release from MSNs. This review presents an overview of the recent progress in the production of pH-responsive MSNs based on the pH gradient between normal tissues and the tumor microenvironment. Four main categories of gatekeepers can respond to acidic conditions. hTese categories will be described in detail.
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