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目的:评价枸杞果汁对人体免疫系统的影响。方法:选择60名志愿者作为受试对象随机分为干预组(n=30)和安慰剂组(n=30),采用双盲法给予受试物,每日2次,每次60 ml,连续30 d。试验前后分别进行常规体检、临床症状观察、视力测定、短时注意力和记忆力测定、血清免疫指标测定。结果:志愿者饮用枸杞果汁和安慰剂30 d后,干预组临床症状有明显改善,与自身试验前及安慰剂组比较差别有统计学意义(P<0.05);干预组与安慰剂组主要症状改善总有效率分别为63.33%、20.00%,两者比较差别有统计学意义(P<0.05);干预组淋巴细胞转化能力、IL-2、IgG含量与试食前及安慰剂组试验后比较,均有显著提高(P<0.05);干预组CD4、CD8、NK、IL-4、IgA水平未见明显改变;干预组短时注意力和记忆力与试食前及安慰剂组比较差别无统计学意义;干预组视力水平未见明显改变。试验期间未见志愿者有明显不良反应,各项安全性指标均未见明显异常改变。结论:枸杞果汁能有效地调节人体免疫系统。
Objective: To evaluate the effect of wolfberry juice on the human immune system. Methods: Sixty volunteers were randomly divided into intervention group (n = 30) and placebo group (n = 30). The subjects were given double-blind method twice daily for 60 ml, Continuous 30 d. Before and after the test were routine physical examination, clinical symptoms, visual acuity, short-term attention and memory determination, serum immune parameters. Results: After 30 days of drinking medlar juice and placebo, the clinical symptoms of the intervention group were significantly improved, which were significantly different from those of the placebo group and the placebo group (P <0.05). The main symptoms of intervention group and placebo group The total effective rate was 63.33% and 20.00%, respectively. There was significant difference between the two groups (P <0.05). The levels of lymphocyte transformation, IL-2 and IgG in the intervention group were significantly higher than those in the pre-test and placebo groups (P <0.05). The levels of CD4, CD8, NK, IL-4 and IgA in the intervention group did not change significantly. The short-term attentiveness and memory of intervention group were not significantly different from pre-test and placebo group There was no significant change in eyesight in intervention group. No volunteers during the trial showed significant adverse reactions, the safety indicators were no significant abnormal changes. Conclusion: Chinese wolfberry juice can effectively regulate the body’s immune system.