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从热力学推导可知,分子与较大的实体间通过多重非共价作用的结合,其结合能大于这些作用力分别单独作用时结合能的加和,即多重非共价作用之间存在协同效应。本文讨论了多重非共价作用(如疏水作用、离子作用、氢键等)及其协同效应在吸附体系和药物控释体系的设计中的应用,一些单独作用时对结合可能没有贡献的非共价作用(如水介质中的氢键),与其它作用同时发生时对结合可能有贡献。合理利用多重非共价作用及其协同效应不仅能提高吸附量和药物负载量,而且还能调控不同吸附质间的吸附选择性和药物的控制释放性能。
From the deduction of thermodynamics, it can be known that the combination of multiple non-covalent interactions between molecules and larger entities is greater than the sum of binding energies when these forces act alone, ie, the synergistic effect exists between multiple non-covalent interactions. This article discusses the application of multiple non-covalent interactions (such as hydrophobic interactions, ionic interactions, hydrogen bonding, etc.) and their synergistic effects in the design of adsorption systems and drug delivery systems. Some of these non-covalent interactions that may not contribute to binding The valence effect (such as hydrogen bonding in aqueous media) may contribute to binding when taken concurrently with other effects. The rational use of multiple non-covalent effects and their synergistic effects can not only improve the adsorption capacity and drug load, but also control the adsorption selectivity and drug release performance of different adsorbates.